Mind the Brain

How to get a flawed systematic review and meta-analysis withdrawn from publication: a detailed example

Cochrane normally requires authors to agree to withdraw completed reviews that have been published. This withdrawal in the face of resistance from the authors is extraordinary. There is a lot to be learned from this letter and the accompanying documents in terms of Courtney calmly and methodically laying out a compelling case for withdrawal of a review with important clinical practice and policy implications.

The PACE PLOS One data will not be released and the article won’t be retracted

PLOS One has bought into discredited arguments about patient consent forms not allowing sharing of anonymized data. PLOS One is no longer at the vanguard of open science through routine data sharing.

Before you enroll your child in the MAGENTA chronic fatigue syndrome study: Issues to be considered

[October 3 8:23 AM Update: I have now inserted Article 21 of the Declaration of Helsinki below, which is particularly relevant to discussions of the ethical problems of Dr. Esther Crawley’s previous SMILE trial.] Petitions are calling for shutting down the MAGENTA trial. Those who organized the effort and signed the petition are commendably brave, … Continue reading "Before you enroll your child in the MAGENTA chronic fatigue syndrome study: Issues to be considered"

Why the scientific community needs the PACE trial data to be released

University and clinical trial investigators must release data to a citizen-scientist patient, according to a landmark decision in the UK. But the decision could still be overturned if the University and investigators appeal. The scientific community needs the decision to be upheld. I’ll argue that it’s unwise for any appeal to be made. The reasons … Continue reading "Why the scientific community needs the PACE trial data to be released"

Uninterpretable: Fatal flaws in PACE Chronic Fatigue Syndrome follow-up study

Earlier decisions by the investigator group preclude valid long-term follow-up evaluation of CBT for chronic fatigue syndrome (CFS). At the outset, let me say that I’m skeptical whether we can hold the PACE investigators responsible for the outrageous headlines that have been slapped on their follow-up study and on the comments they have made in … Continue reading "Uninterpretable: Fatal flaws in PACE Chronic Fatigue Syndrome follow-up study"