Mind the Brain

The PACE PLOS One data will not be released and the article won’t be retracted

PLOS One has bought into discredited arguments about patient consent forms not allowing sharing of anonymized data. PLOS One is no longer at the vanguard of open science through routine data sharing.

Better days: When PLOS Blogs honored my post about fatal flaws in the PACE chronic fatigue syndrome follow-up study (2015)

The back story on my receiving this honor was that PLOS Blogs only days before had shut down the blog site because of complaints from someone associated with the PACE trial. I was asked to resign. I refused. PLOS Blogs relented when I said it would be a publicity disaster for PLOS Blogs.

Power pose: II. Could early career investigators participating in replication initiatives hurt their advancement?

Participation in attempts to replicate seriously flawed studies might be seen as bad judgment, when there many more opportunities to demonstrate independent, critical thinking.

Why PhD students should not evaluate a psychotherapy for their dissertation project

Things some clinical and health psychology students wish they had known before they committed themselves to evaluating a psychotherapy for their dissertation study. A well designed pilot study addressing feasibility and acceptability issues in conducting and evaluating psychotherapies is preferable to an underpowered study which won’t provide a valid estimate of the efficacy of the … Continue reading "Why PhD students should not evaluate a psychotherapy for their dissertation project"

Study protocol violations, outcomes switching, adverse events misreporting: A peek under the hood

An extraordinary, must-read article is now available open access: Jureidini, JN, Amsterdam, JD, McHenry, LB. The citalopram CIT-MD-18 pediatric depression trial: Deconstruction of medical ghostwriting, data mischaracterisation and academic malfeasance. International Journal of Risk & Safety in Medicine, vol. 28, no. 1, pp. 33-43, 2016 The authors had access to internal documents written with the … Continue reading "Study protocol violations, outcomes switching, adverse events misreporting: A peek under the hood"

What patients should require before consenting to participate in research…

A bold BMJ editorial  calls for more patient involvement in the design, implementation, and interpretation of research – but ends on a sobering note: The BMJ has so little such involvement to report. In this edition of Mind the Brain, I suggest how patients, individually and collectively, can take responsibility for advancing this important initiative … Continue reading "What patients should require before consenting to participate in research…"

Why the scientific community needs the PACE trial data to be released

University and clinical trial investigators must release data to a citizen-scientist patient, according to a landmark decision in the UK. But the decision could still be overturned if the University and investigators appeal. The scientific community needs the decision to be upheld. I’ll argue that it’s unwise for any appeal to be made. The reasons … Continue reading "Why the scientific community needs the PACE trial data to be released"